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Opioids in rheumatic diseases.

L J Lang1, M Pierer, C Stein

  • 1Klinik für Anästhesiologie und operative Intensivmedizin, Charité Campus Benjamin Franklin, Freie Universität Berlin, Berlin, Germany. leonie.lang@charite.de

Annals of the New York Academy of Sciences
|April 20, 2010
PubMed
Summary
This summary is machine-generated.

Opioids effectively manage severe pain but their use for chronic noncancer pain, including rheumatic diseases, remains debated due to side effects. This review examines opioid roles and peripheral effects in rheumatic conditions.

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Area of Science:

  • Rheumatology
  • Pain Management
  • Pharmacology

Background:

  • Opioids are potent analgesics for severe acute, surgical, and cancer pain.
  • Chronic noncancer pain (CNCP), particularly from rheumatic diseases like arthritis and low-back pain, presents a significant management challenge.
  • The use of opioids for CNCP is controversial due to potential side effects and regulatory concerns.

Purpose of the Study:

  • To review the role of opioids in managing chronic rheumatic diseases.
  • To outline the peripheral effects of opioids on pain and inflammation in the context of rheumatic diseases.

Main Methods:

  • Literature review focusing on opioid use in chronic rheumatic diseases.
  • Analysis of studies investigating peripheral opioid mechanisms in inflammatory conditions.

Main Results:

  • Opioid efficacy in severe pain is well-established.
  • Significant controversy surrounds opioid use for CNCP due to side effects (tolerance, addiction, withdrawal, etc.).
  • Peripheral opioid effects on pain and inflammation in rheumatic diseases require further elucidation.

Conclusions:

  • Opioid therapy for chronic rheumatic diseases requires careful consideration of benefits versus risks.
  • Understanding peripheral opioid actions may offer new therapeutic strategies for rheumatic pain and inflammation.