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Keratoprostheses in clinical practice - a review
Ahmed Gomaa1, Oliver Comyn, Christopher Liu
1Sussex Eye Hospital, Brighton, UK.
Clinical & Experimental Ophthalmology
|April 20, 2010
Summary
Artificial cornea research, or keratoprosthesis (KPro), has a long history with limited success. Current devices offer visual improvement but have significant limitations, prompting exploration of future innovations.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Regenerative Medicine
Background:
- The quest for artificial cornea substitutes spans over two centuries.
- Few artificial cornea devices have achieved long-term clinical success.
- Keratoprosthesis (KPro) surgery demands specialized multidisciplinary teams.
Purpose of the Study:
- To review current keratoprosthesis (KPro) devices.
- To discuss indications, surgical techniques, and outcomes of KPro.
- To explore emerging artificial cornea technologies.
Main Methods:
- Review of existing literature on keratoprosthesis devices.
- Analysis of clinical data regarding surgical techniques and results.
- Exploration of novel and future artificial cornea approaches.
Main Results:
- Current KPro devices include fully synthetic (e.g., Boston KPro), fully biological, and hybrid (osteo-odonto keratoprosthesis) options.
- All available keratoprostheses present significant limitations.
- Despite limitations, visual improvement is achievable with current KPro devices.
Conclusions:
- Keratoprosthesis surgery is complex and requires expert centers.
- Existing artificial cornea devices have notable drawbacks.
- Future research focuses on innovative solutions for artificial corneas.
