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Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Unmet physical activity need in old age.

Merja Rantakokko1, Susanne Iwarsson, Mirja Hirvensalo

  • 1Department of Health Sciences, Finnish Centre for Interdisciplinary Gerontology, University of Jyväskylä, Jyväskylä, Finland. merja.rantakokko@jyu.fi

Journal of the American Geriatrics Society
|April 20, 2010
PubMed
Summary

Unmet physical activity need is common in older adults, especially those with health and mobility issues. Environmental factors like hills and unsafe streets contribute, highlighting the need for accessible solutions.

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Area of Science:

  • Gerontology
  • Public Health
  • Environmental Health

Background:

  • Older adults often experience unmet physical activity need, impacting their well-being.
  • Understanding factors influencing this need is crucial for promoting active aging.

Purpose of the Study:

  • To identify individual and environmental correlates of unmet physical activity need in older adults.
  • To predict the development of unmet physical activity need over a two-year period.

Main Methods:

  • Observational prospective cohort study with cross-sectional analyses.
  • 643 community-living older adults (75-81 years) assessed at baseline; 314 at 2-year follow-up.
  • Interviews and examinations assessed unmet physical activity need, correlates, and development.

Main Results:

  • 14% of participants reported unmet physical activity need at baseline.
  • Prevalence linked to musculoskeletal diseases, depressive symptoms, and mobility limitations.
  • Environmental factors (hills, lack of rest stops, dangerous crossroads) and fear of moving outdoors predicted incident unmet need.

Conclusions:

  • Unmet physical activity need is prevalent in ambulatory older adults with health/mobility issues and negative neighborhood features.
  • Developing solutions to overcome physical activity barriers is essential for equitable participation.