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Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells
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Published on: December 29, 2012

New role for Agrin in T cells and its potential importance in immune system regulation

Elizabeth C Jury1, Panagiotis S Kabouridis

  • 1Centre for Rheumatology, Royal Free and University College Medical School, University College London, London W1P 4JF, UK. e.jury@ucl.ac.uk

Arthritis Research & Therapy
|April 20, 2010
PubMed

Agrin plays a crucial role in the maintenance of the neuromuscular junction. However, it is expressed in other tissues as well, including T lymphocytes, where cell activation induces its expression. Agrin from activated T cells has the capacity to induce aggregation of key receptors and to regulate signalling. Interestingly, T cells isolated from patients with systemic lupus erythematosus over-express Agrin and its co-stimulation with the T cell receptor enhances production of pathogenic cytokines. These early studies point to an important function for Agrin in T cell biology and make the case for a more thorough and systematic investigation into its role in the immune system.

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