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Updated: Jun 13, 2026

Expression, Purification, and Antimicrobial Activity of S100A12
Published on: May 13, 2017
[S100A8, S100A9 and S100A12 proteins in rheumatoid arthritis]
1Clinique universitaire de rhumatologie, CHU hôpital Sud, avenue de Kimberley, BP 338, 38434 Echirolles cedex, France. abaillet@chu-grenoble.fr
Abstract:
Although S100 proteins represent 40% of the neutrophil cytoplasmic proteins, their physiological and pathological functions are still unclear. S100A8, S100A9 and S100A12 protein concentrations are dramatically enhanced in synovial fluid and synovium of patients suffering from rheumatoid arthritis. Their expression seems to correlate with disease activity and joint damage. These proteins are likely involved in rheumatoid arthritis pathogenesis by enhancing extracellular matrix proteolysis, autoimmunity and inducing the pseudotumoral phenotype of the synoviocytes in rheumatoid arthritis. S100A8, S100A9 and S100A12 assessment will probably constitute a relevant tool for rheumatoid arthritis diagnosis and will improve inflammatory arthritides management.
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