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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Related Experiment Video

Updated: Jun 13, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

[Microchimerism in scleroderma: ten years later].

N-C Lambert1

  • 1Laboratoire immunogénétique de la polyarthrite rhumatoïde, Inserm UMR639, parc scientifique de Luminy, bâtiment TPR2-entrée A, 1(er) étage, 163, avenue de Luminy, 13288 Marseille cedex 9, France. nathalie.lambert@inserm.fr

La Revue De Medecine Interne
|April 20, 2010
PubMed
Summary
This summary is machine-generated.

Foetal microchimerism (Mc), cells from a fetus in a mother, may cause autoimmune reactions like in systemic sclerosis (SSc). Research shows Mc can be harmful or beneficial, offering therapeutic hope.

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Area of Science:

  • Immunology
  • Reproductive Biology
  • Genetics

Context:

  • Foetal microchimerism (Mc) involves cells from a fetus residing in the mother.
  • A decade-old hypothesis suggests Mc may trigger adverse immune responses, potentially causing autoimmune diseases like systemic sclerosis (SSc).
  • Initial studies found higher Mc levels in SSc patients, but subsequent research yielded contradictory results.

Purpose:

  • To review and reconcile conflicting findings on the role of foetal microchimerism in disease.
  • To explore factors influencing the behavior of microchimeric cells.
  • To assess the potential for therapeutic interventions targeting microchimerism.

Summary:

  • Foetal microchimerism (Mc) is the presence of fetal cells within the maternal host.
  • While initially linked to autoimmune diseases like SSc, the role of Mc is complex and results have been inconsistent.
  • Environmental and genetic factors dictate whether microchimeric cells exhibit harmful or beneficial effects.

Impact:

  • Understanding Mc's dual nature (harmful vs. beneficial) is crucial for disease etiology.
  • Identifying factors modulating Mc behavior could lead to novel diagnostic markers.
  • The potential for microchimeric cells to revert to a non-aggressive phenotype offers new therapeutic avenues for autoimmune conditions.