Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined nasopharyngeal and oropharyngeal sampling improves pathogen detection in community-acquired pneumonia.

Frontiers in microbiology·2026
Same author

Epidemiology and antimicrobial resistance patterns of Aeromonas species in Europe, 2020-2024 (AEuROMONAS).

Diagnostic microbiology and infectious disease·2026
Same author

Pneumococcal serotype epidemiology and resistance after PCV13 replacement with PCV10, Sweden.

The Journal of infection·2026
Same author

Minor non-fermenting Gram-negative bacilli in Europe, 2020-2024 (MINOFEu).

International journal of antimicrobial agents·2026
Same author

Activity of cefepime/enmetazobactam against highly multidrug-resistant bacterial isolates recovered from war-associated wounds in Ukraine.

JAC-antimicrobial resistance·2026
Same author

Intracellular C3 regulates the immune response to infection via NF-κB signaling.

Cellular and molecular life sciences : CMLS·2025

Related Experiment Video

Updated: Jun 13, 2026

Assessing Respiratory Immune Responses to Haemophilus Influenzae
06:32

Assessing Respiratory Immune Responses to Haemophilus Influenzae

Published on: June 29, 2021

Haemophilus influenzae and the complement system.

Teresia Hallström1, Kristian Riesbeck

  • 1Medical Microbiology, Department of Laboratory Medicine Malmö, Lund University, Skåne University Hospital, SE-205 02 Malmö, Sweden.

Trends in Microbiology
|April 20, 2010
PubMed
Summary
This summary is machine-generated.

Haemophilus influenzae evades the human complement system using multiple strategies, including bacterial surface modifications. Understanding these mechanisms is key for developing new treatments for infections caused by this pathogen.

More Related Videos

Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance
10:55

Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance

Published on: October 16, 2018

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Related Experiment Videos

Last Updated: Jun 13, 2026

Assessing Respiratory Immune Responses to Haemophilus Influenzae
06:32

Assessing Respiratory Immune Responses to Haemophilus Influenzae

Published on: June 29, 2021

Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance
10:55

Assays for Studying the Role of Vitronectin in Bacterial Adhesion and Serum Resistance

Published on: October 16, 2018

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Area of Science:

  • Microbiology
  • Immunology

Background:

  • Haemophilus influenzae is a significant respiratory pathogen causing various human infections.
  • Pathogenesis involves evading host defenses, particularly the complement system.
  • Effective complement evasion enhances bacterial survival and virulence.

Purpose of the Study:

  • To provide an overview of Haemophilus influenzae complement evasion mechanisms.
  • To highlight the importance of understanding these mechanisms for pathogenesis and therapeutic development.

Main Methods:

  • Review of current scientific literature on Haemophilus influenzae and complement interaction.
  • Analysis of known bacterial factors involved in complement resistance.

Main Results:

  • Haemophilus influenzae employs diverse strategies to resist complement-mediated attack.
  • Mechanisms include attracting host complement regulators and utilizing bacterial surface components like capsule and outer membrane proteins.
  • These strategies contribute to bacterial survival against host immune responses.

Conclusions:

  • Haemophilus influenzae possesses sophisticated mechanisms to evade the complement system.
  • Further research into these evasion tactics is crucial for developing effective vaccines and therapies, especially for vulnerable populations like those with COPD.