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Do endogenous excitatory amino acids influence striatal dopamine release?
1Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510.
Brain Research
|March 29, 1991
Summary
Excitatory amino acids do not tonically facilitate striatal dopamine release. High doses of NMDA and non-NMDA antagonists enhanced dopamine release, contradicting a tonic facilitatory role.
Area of Science:
- Neuroscience
- Neurochemistry
Background:
- Endogenous excitatory amino acids play crucial roles in neurotransmission.
- Their influence on basal dopamine release in the striatum is not fully understood.
Purpose of the Study:
- To investigate the tonic facilitatory influence of endogenous excitatory amino acids on striatal dopamine release.
- To determine the effects of NMDA and non-NMDA antagonists on dopamine release in vivo.
Main Methods:
- In vivo microdialysis was employed to measure striatal dopamine release.
- Local administration of NMDA and non-NMDA antagonists at varying concentrations (10 microM, 100 microM, 1 mM) was performed.
Main Results:
- Low concentrations (10 microM) of NMDA and non-NMDA antagonists had no effect on basal dopamine release.
- Higher concentrations (100 microM and 1 mM) of these antagonists significantly enhanced striatal dopamine release.
Conclusions:
- The results do not support a tonic excitatory effect of endogenous excitatory amino acids on striatal dopamine release.
- The findings suggest a more complex interaction, potentially involving inhibitory mechanisms at higher antagonist concentrations.