Related Experiment Video
Updated: Jun 13, 2026
15:17
Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
Published on: September 25, 2011
Enteropathy-associated T-cell lymphoma--a clinicopathologic and array comparative genomic hybridization study
Young Hyeh Ko1, Sivasundaram Karnan, Kyeong Mee Kim
1Department of Pathology, Samsung Medical Center, Sungkyunkwan University, Kangnamgu, Seoul 135-710, Korea. yhko310@skku.edu
Human Pathology
|April 20, 2010
Summary
Enteropathy-associated T-cell lymphoma (EATL) in Korea is predominantly type 2, not linked to celiac disease. Genetic alterations in Korean EATL mirror those found in Western populations, suggesting a shared underlying biology.
Area of Science:
- Gastroenterology
- Oncology
- Genetics
Background:
- Enteropathy-associated T-cell lymphoma (EATL) is classified into two types by the WHO: type 1 (celiac disease-associated) and type 2 (celiac disease-unassociated).
- Understanding the prevalence and characteristics of EATL types in different geographic regions is crucial for diagnosis and treatment.
Purpose of the Study:
- To characterize the clinicopathologic, immunophenotypic, and genomic profiles of EATL in Korea.
- To determine the predominant type of EATL in the Korean population.
Main Methods:
- Clinicopathologic and immunophenotypic analyses of 8 Korean EATL cases.
- Array comparative genomic hybridization (aCGH) for genomic profiling.
- Analysis of HLA DQB10302 allele and association with gluten-sensitive malabsorption.
Main Results:
- All 8 patients exhibited intraepithelial lymphocytosis; none had gluten-sensitive malabsorption.
- EATL type 2 was the predominant type, with tumors located in the small intestine (5 cases) and colorectum (3 cases).
- Recurrent genomic alterations included gain of 9q33-q34.1 (80%), 6p21.1-21.31 (60%), and 19q (40%), and loss of 3p12.1-p12.2 (40%) and 3q26.31 (40%).
Conclusions:
- The most prevalent type of EATL in Korea is type 2, consistent with findings in Western countries.
- The genetic alterations observed in Korean EATL are similar to those reported in Western populations, indicating conserved molecular pathways.
