Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cranial Nerves: Types Part I

Cranial Nerves: Types Part I

Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves, with the first six being essential in sensory perception, motor control, and autonomic functions related to the head and neck.
Olfactory Nerve (Cranial Nerve I)
The olfactory nerve, or cranial nerve I, is unique as it is purely sensory and dedicated to the sense of smell. This nerve originates in the olfactory epithelium of the...

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Caffeine makes a splash: a systematic review and multilevel meta-analysis exploring the effects of caffeine intake on swimming performance.

Journal of the International Society of Sports Nutrition·2026

Same author

Effects of caffeinated gum doses combined with post-activation performance enhancement on bench-press bar velocity: a randomized crossover study.

Frontiers in nutrition·2026

Same author

In water or on land? A network meta-analysis of aquatic and land-based exercise interventions for pain and disability in chronic lower back pain.

Frontiers in medicine·2026

Same author

Spectral principal axis system (SPAS) and tuning of tensor-valued encoding for microscopic anisotropy and time-dependent diffusion in the rat brain.

Imaging neuroscience (Cambridge, Mass.)·2025

Same author

Tracking Hyperpolarized [1-<sup>13</sup>C] Pyruvate and [1-<sup>13</sup>C] L-Lactate Metabolism in the Healthy and Post-Stroke Mouse Brain.

NMR in biomedicine·2025

Same author

Views of people with MS regarding VR-exergaming to improve physical function and cognition: a qualitative study.

Disability and rehabilitation·2025

Same journal

Repeatability of an MRI protocol for generating habitats based on cellularity, perfusion, and hypoxia in a murine model of glioma.

Magnetic resonance imaging·2026

Same journal

Association between CMR-derived pulmonary artery pulse wave velocity and pulmonary risk factors: the multi-ethnic study of atherosclerosis COPD study.

Magnetic resonance imaging·2026

Same journal

Systematic comparison of MPRAGE and BRAVO T1-weighted MRI pulse sequences and brain morphometry in high-risk young adults.

Magnetic resonance imaging·2026

Same journal

Foot dynamic contrast-enhanced MRI for assessing microcirculatory changes after endovascular therapy in peripheral artery disease: A prospective pilot study.

Magnetic resonance imaging·2026

Same journal

Reconstruction of MRI from undersampled k-spaces of double-contrast volume acquisitions using deep neural networks.

Magnetic resonance imaging·2026

Same journal

Radiofrequency-induced heating safety of brain MRI scans at 7 T in the presence of a shoulder implant.

Magnetic resonance imaging·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

In-Vivo Calcium Imaging of Sensory Neurons in the Rat Trigeminal Ganglion

In-Vivo Calcium Imaging of Sensory Neurons in the Rat Trigeminal Ganglion

Published on: February 9, 2024

BOLD responses to trigeminal nerve stimulation.

Nathalie Just¹, Carl Petersen, Rolf Gruetter

¹Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. nathalie.just@epfl.ch

Magnetic Resonance Imaging

|April 20, 2010

Summary

This summary is machine-generated.

Researchers developed a new rat model for barrel cortex activation using trigeminal nerve stimulation. This model provides insights into functional magnetic resonance imaging (fMRI) signal interpretation, particularly blood oxygen level-dependent (BOLD) responses.

More Related Videos

$Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain$

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia

Published on: August 1, 2025

Related Experiment Videos

Last Updated: Jun 13, 2026

In-Vivo Calcium Imaging of Sensory Neurons in the Rat Trigeminal Ganglion

In-Vivo Calcium Imaging of Sensory Neurons in the Rat Trigeminal Ganglion

Published on: February 9, 2024

$Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain$

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain

Published on: May 10, 2017

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Trigeminal Ganglia

Published on: August 1, 2025

Area of Science:

Neuroscience
Neuroimaging
Systems Neuroscience

Background:

The rat barrel cortex processes sensory information from whiskers.
Understanding barrel cortex activation is crucial for interpreting functional magnetic resonance imaging (fMRI) studies.

Purpose of the Study:

To establish a novel model for barrel cortex activation using infraorbital nerve stimulation.
To characterize the blood oxygen level-dependent (BOLD) responses in the rat barrel cortex.

Main Methods:

Stimulation of the infraorbital branch of the trigeminal nerve in rats.
Measurement of BOLD signals in the primary somatosensory barrel cortex (S1BF), secondary somatosensory cortex (S2), and motor cortex.
Modeling of BOLD responses using cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO(2)) measurements.

Main Results:

A robust and reproducible BOLD response was observed in the barrel cortex and associated areas.
Optimal stimulation parameters identified: 1 Hz frequency, 100 μs pulse width, and 1.5–3 mA current intensity.
BOLD responses exhibited nonlinearity with respect to stimulus frequency and current intensity.

Conclusions:

Trigeminal nerve stimulation provides a viable method for activating the rat barrel cortex.
The developed model aids in understanding the physiological basis of BOLD signals.
This research contributes to the interpretation of fMRI data in sensory processing studies.