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Published on: February 23, 2014
[Bacteremia in febrile children]
1Department of Pediatrics, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
Insights
Bacteremia in febrile children under two is uncommon, with a 2% incidence in this study. Neither white blood cell count nor temperature reliably predicted bacteremia in young patients.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Context:
- Bacteremia in young children with fever is a concern due to potential serious complications like meningitis.
- Previous research suggests a low incidence but significant risk in specific pediatric populations.
- The study focuses on febrile children presenting to an emergency department without apparent serious illness or viral infection.
Purpose:
- To determine the incidence of bacteremia in febrile children aged under 15 in the Taipei area.
- To evaluate the predictive value of white blood cell (WBC) count and body temperature for bacteremia in this population.
- To identify common pathogens causing bacteremia in different pediatric age groups.
Summary:
- A study of 300 febrile children (body temperature >= 39°C) in Taipei found an overall bacteremia incidence of 2% (6/300).
- Incidence was highest in neonates (13%) and infants aged 1 month to 1 year (5%), with pathogens including Group D Streptococcus, Streptococcus viridans, Escherichia coli, and Salmonella species.
- Neither elevated white blood cell count nor high body temperature demonstrated predictive value for bacteremia in the studied children.
Impact:
- This research highlights the low incidence of bacteremia in febrile children who appear well, challenging the utility of routine WBC counts and temperature for prediction.
- Findings suggest that clinical assessment may be more crucial than simple laboratory markers in identifying bacteremia risk in this age group.
- The study provides valuable epidemiological data on bacteremia pathogens in Taiwanese children, aiding in targeted treatment strategies.
Abstract:
Bacteremia in children under 2 years of age is not uncommon. Several studies indicated that a small proportion of young children with fever who do not appear to be seriously ill may have bacteremia, and a small proportion of this subgroup may go on to develop serious illness such as meningitis. The rationale for this study was to assess both the incidence of bacteremia in febrile children in Taipei area and the predictive value of the white blood cell count and degree of body temperature for bacteremia. Three hundred febrile children (B. T. greater than or equal to 39 degrees C), without underlying disease or readily recognizable viral illness, who visited the emergency service of Chang Gung Memorial Hospital, were enrolled. Blood cultures and complete blood counts were obtained. Clinically important pathogens were identified in 6 of 300 cases (2%). The incidence and pathogens of various age group were: (1) Neonate, 2/15 (13%), one each of Group D streptococcus & streptococcus viridans; (2) 1 month to 1 year old, 3/66 (5%), 2 Escherichia coli and 1 Salmonella Group D; (3) 1 to 2 years old, 0/49; (4) 2 to 5 years old, 0/72; (5) 5 to 10 years old, 0/67; (6) 10 to 15 years old, 1/26 (4%), Salmonella typhosa. Neither the white blood cell count, the absolute segmented or band neutrophil count, nor the degree of body temperature had predictive value for bacteremia.
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