Related Experiment Video

Updated: Jun 13, 2026

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format
05:58

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Published on: August 20, 2018

Jejunal cancer in patients with familial adenomatous polyposis

Anthony T Ruys1, Yasser A Alderlieste, Dirk J Gouma

  • 1Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|April 20, 2010
PubMed

Insights

Familial adenomatous polyposis (FAP) patients can develop jejunal (small intestine) cancers, which are associated with a poor prognosis. Further research is needed to identify FAP patients who may benefit from jejunal surveillance.

Area of Science:

  • Gastroenterology
  • Oncology
  • Genetics

Background:

  • Familial adenomatous polyposis (FAP) is an inherited condition affecting approximately 1 in 10,000 newborns, characterized by numerous digestive tract adenomas.
  • While colonic and duodenal manifestations are well-studied, adenoma formation in FAP is now recognized to occur in other areas of the digestive tract.
  • The malignant potential of these non-colonic, non-duodenal adenomas remains largely unknown.

Observation:

  • This study reports three cases of jejunal carcinoma in FAP patients, aged 71, 57, and 59.
  • All three patients presented with advanced duodenal adenomatosis.
  • Two of the three patients experienced a poor prognosis due to their jejunal carcinoma.

Findings:

  • Jejunal adenomas, though occasionally reported in FAP, can progress to adenocarcinoma.
  • Jejunal adenocarcinoma in FAP patients is associated with a poor prognosis, as evidenced by the cases presented.
  • The incidence, prognosis, and risk factors for jejunoileal adenoma and carcinoma in FAP require further investigation.

Implications:

  • The findings suggest that jejunal surveillance may be beneficial for a subset of FAP patients.
  • Identifying specific risk factors and patient subgroups for jejunal surveillance is crucial for improving outcomes.
  • This research highlights the need to consider the entire digestive tract when managing FAP patients.
Abstract

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