Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ENPP3 CAR T cells combined with CD206 modulation suppress adrenocortical carcinoma.

Journal for immunotherapy of cancer·2026
Same author

BRAF V600E Expression in c-Kit+ Interstitial Cells of Cajal Drives Gastrointestinal Stromal Tumor Formation in Mice.

Cancer research communications·2026
Same author

Investigating fatigue in adults with neuroendocrine neoplasms using a biopsychosocial model.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2025
Same author

A unified framework governing the establishment and maintenance of transgenerational epigenetic inheritance.

Genetics·2025
Same author

Moving epigenetic inheritance into the space age: Evidence that 3D genome organization is required for the establishment of epigenetic memory.

Molecular cell·2025
Same author

Germline findings in cancer predisposing genes from a small cohort of chordoma patients.

Journal of cancer research and clinical oncology·2024

Related Experiment Video

Updated: Jun 13, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Genetically engineered mouse models in cancer research.

Jessica C Walrath1, Jessica J Hawes, Terry Van Dyke

  • 1Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland, USA.

Advances in Cancer Research
|April 20, 2010
PubMed
Summary
This summary is machine-generated.

Engineered mouse models are crucial for cancer research, enabling a deeper understanding of tumor development and guiding the creation of new therapies. These advanced models improve the accuracy of human cancer studies and aid in developing diagnostic and treatment strategies.

More Related Videos

Somatic Genome-Engineered Mouse Models Using In Vivo Microinjection and Electroporation
08:06

Somatic Genome-Engineered Mouse Models Using In Vivo Microinjection and Electroporation

Published on: May 5, 2023

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

Related Experiment Videos

Last Updated: Jun 13, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Somatic Genome-Engineered Mouse Models Using In Vivo Microinjection and Electroporation
08:06

Somatic Genome-Engineered Mouse Models Using In Vivo Microinjection and Electroporation

Published on: May 5, 2023

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

Area of Science:

  • Oncology and Cancer Research
  • Genetics and Genomics
  • Immunology

Background:

  • Mouse models are indispensable for studying human tumorigenesis and addressing complex experimental questions.
  • Continuous advancements in mouse modeling enhance our understanding of tumor development mechanisms.

Purpose of the Study:

  • To review significant progress in mouse models for cancer research.
  • To highlight how these models facilitate the exploration of specific research areas in oncology.
  • To discuss the role of mouse models in developing therapeutic and diagnostic strategies.

Main Methods:

  • Utilizing engineered mouse models with controlled timing and location of mutations, even at the single-cell level.
  • Employing mouse models to test hypotheses generated from human and cell culture systems in vivo.
  • Leveraging models to study the tumor microenvironment, including interactions with surrounding stroma.
  • Developing models for in vivo imaging to track primary and metastatic tumor development.

Main Results:

  • Mouse models have significantly advanced understanding of cancer initiation, immune roles, angiogenesis, invasion, and metastasis.
  • These models accurately reflect the molecular diversity observed in human cancers.
  • The tumor microenvironment's critical role in tumorigenesis has been established through these models.
  • New models enable more precise replication of sporadic human cancers.

Conclusions:

  • Engineered mouse models are essential for validating cancer hypotheses in vivo.
  • Advances in mouse modeling are crucial for identifying novel therapeutic and diagnostic strategies.
  • These models are instrumental in guiding clinical research for treatment, diagnosis, and patient stratification.