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Updated: Jun 13, 2026
11:29
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
Androgen regulation of gene expression
Kristin R Lamont1, Donald J Tindall
1Department of Urology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
Advances in Cancer Research
|April 20, 2010
Summary
Androgen receptor signaling controls prostate cell functions through thousands of genes. This review summarizes recent findings on androgen-regulated genes and receptor activity in prostate cancer.
Area of Science:
- Endocrinology
- Molecular Biology
- Oncology
Background:
- Androgenic male sex steroid hormones are crucial for prostate tissue function.
- The androgen receptor (AR) acts as a nuclear transcription factor mediating hormone action.
- AR signaling regulates numerous cellular functions, including proliferation, survival, and differentiation.
Purpose of the Study:
- To review recent data on androgen-regulated target genes in the prostate.
- To summarize the modulation of androgen receptor activity.
- To focus on androgen-dependent and castration-recurrent prostate cancer.
Main Methods:
- Literature review of recent scientific data.
- Analysis of androgen-regulated gene targets.
- Examination of androgen receptor activity modulation.
Main Results:
- Androgen receptor signaling impacts thousands of prostate gene targets.
- Key cellular functions like proliferation and metabolism are androgen-regulated.
- Modulation of AR activity is critical in prostate cancer progression.
Conclusions:
- Understanding androgen-regulated genes is vital for prostate cancer research.
- Targeting AR activity offers therapeutic strategies for prostate cancer.
- Recent advancements provide new insights into AR signaling in recurrent prostate cancer.
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