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Related Concept Videos

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:

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Related Experiment Video

Updated: Jun 13, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Colorectal cancer screening - methodology.

F Jenkinson1, R J C Steele

  • 1Department of Surgery and Oncology, Ninewells Hospital and Medical School, University of Dundee, Scotland DD1 9SY, UK. fiona.jenkinson@nhs.net

The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
|April 20, 2010
PubMed
Summary
This summary is machine-generated.

Colorectal cancer (CRC) screening aims to detect the disease early using methods like fecal occult blood tests or stool DNA mutation analysis. Identifying specific gene mutations (K-ras, BRAF, p53, APC) in stool shows promise for improved CRC detection.

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Published on: September 25, 2011

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Last Updated: Jun 13, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
15:17

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

Area of Science:

  • Oncology
  • Gastroenterology
  • Molecular Diagnostics

Background:

  • Colorectal cancer (CRC) presents a significant global health challenge, with high incidence in developed nations and ranking as the third most common cancer in Scotland.
  • Late symptom manifestation in CRC necessitates early detection strategies through effective screening programs.
  • Current screening methods include fecal occult blood testing, colonoscopy, and molecular analysis of stool samples.

Purpose of the Study:

  • To explore and evaluate various screening modalities for early detection of colorectal cancer.
  • To investigate the potential of identifying specific DNA mutations and proteins in stool as biomarkers for CRC.
  • To assess candidate gene mutations (K-ras, BRAF, p53, APC) for their utility in CRC screening.

Main Methods:

  • Review of established colorectal cancer screening techniques, including flexible sigmoidoscopy and colonoscopy.
  • Analysis of stool samples for the presence of occult blood.
  • Investigating the detection of DNA mutations (K-ras, BRAF, p53, APC) and protein markers in stool specimens.

Main Results:

  • Fecal occult blood testing is a common screening approach.
  • Alternative methods like flexible sigmoidoscopy, colonoscopy, and radiological investigations are available.
  • Identification of specific DNA mutations (K-ras, BRAF, p53, APC) in stool offers a promising avenue for early CRC detection.

Conclusions:

  • Early detection of colorectal cancer is crucial due to late-stage symptom presentation.
  • Stool-based molecular markers, including DNA mutations in K-ras, BRAF, p53, and APC, represent a valuable area for CRC screening development.
  • Combining multiple mutation markers may enhance the accuracy of identifying individuals with colorectal cancer.