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Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...

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Related Experiment Video

Updated: Jun 13, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

[Cryptococcus meningitis in an immunocompetent child: a case report].

M Ndiaye1, R Hagerimana, N S Diagne

  • 1Service de neurologie, CHU Fann, Dakar, Sénégal. ngouille@hotmail.com

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|April 20, 2010
PubMed
Summary

Cryptococcus meningitis is rare in children. This case highlights a fatal outcome in an immunocompetent Senegalese boy despite treatment.

Related Experiment Videos

Last Updated: Jun 13, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Area of Science:

  • Pediatric Infectious Diseases
  • Neuroinfectious Diseases
  • Mycology

Background:

  • Cryptococcus meningitis is an opportunistic infection rarely seen in immunocompetent children.
  • Early diagnosis and treatment are crucial for managing central nervous system infections.

Observation:

  • A 9-year-old boy presented with acute meningoencephalitis.
  • Cerebrospinal fluid analysis confirmed Cryptococcus neoformans infection.
  • Brain imaging revealed an ischemic lesion.

Findings:

  • The child was apparently immunocompetent, with normal CD4 lymphocyte count and no other risk factors.
  • Intravenous fluconazole treatment was unsuccessful.
  • The patient died within one month due to cardiovascular and respiratory complications.

Implications:

  • This case underscores the potential for severe Cryptococcus meningitis in immunocompetent children.
  • It highlights challenges in treating pediatric neuroinfections, even with appropriate antifungal therapy.
  • Further research into risk factors and optimal treatment strategies for pediatric cryptococcosis is warranted.