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Related Concept Videos

Taste Buds and Receptors01:20

Taste Buds and Receptors

Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
The Physiology of Taste01:24

The Physiology of Taste

The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the diffusion of...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
The Tongue and Taste Buds00:49

The Tongue and Taste Buds

The surface of the tongue is covered with various small bumps called papillae, which either distribute what has been ingested (filiform papillae) or contain the sensory taste (or gustatory) receptor cells (fungiform, circumvallate, and foliate papillae). Embedded within each taste-related papilla are the taste buds—clusters of 30 to 100 gustatory receptor cells.

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Related Experiment Video

Updated: Jun 13, 2026

Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells
07:57

Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells

Published on: April 5, 2021

Taste dysfunction in head and neck malignancy.

S R Porter1, S Fedele, K M Habbab

  • 1Oral Medicine and Special Needs Dentistry, UCL Eastman Dental Institute, 256 Grays Inn Road, London WC1X 8LD, United Kingdom. s.porter@eastman.ucl.ac.uk

Oral Oncology
|April 20, 2010
PubMed
Summary
This summary is machine-generated.

Radiotherapy for head and neck cancer often causes taste disturbance, impacting health and quality of life. Effective strategies are needed to prevent and treat this common side effect.

More Related Videos

Taste Exam: A Brief and Validated Test
07:10

Taste Exam: A Brief and Validated Test

Published on: August 17, 2018

Related Experiment Videos

Last Updated: Jun 13, 2026

Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells
07:57

Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells

Published on: April 5, 2021

Taste Exam: A Brief and Validated Test
07:10

Taste Exam: A Brief and Validated Test

Published on: August 17, 2018

Area of Science:

  • Oncology
  • Otorhinolaryngology
  • Medical Science

Background:

  • Radiotherapy for head and neck cancer frequently leads to taste disturbances.
  • These taste disturbances negatively impact patients' overall health and quality of life.
  • Current therapeutic interventions for taste dysfunction are often problematic.

Purpose of the Study:

  • To review the current understanding of taste dysfunction in patients with head and neck malignancy.
  • To highlight the need for improved preventative and curative strategies for radiotherapy-associated taste disturbance.

Main Methods:

  • Literature review of current knowledge on taste dysfunction following head and neck radiotherapy.

Main Results:

  • Taste disturbance is a prevalent complication of head and neck radiotherapy.
  • The mechanisms and clinical impact of radiotherapy-induced taste dysfunction require further investigation.

Conclusions:

  • There is a significant need for effective strategies to manage taste disturbances after head and neck radiotherapy.
  • Further research is essential to develop better preventative and therapeutic options for patients experiencing taste dysfunction.