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Updated: Jun 13, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
No evidence for a polyomavirus association or aetiology in AIDS-associated nonsmall cell lung cancer
Justin Stebbing1, Colin Wickenden, Leandro Castellano
1Department of Oncology, Imperial College School of Medicine, Hammersmith Hospital, London, UK. j.stebbing@imperial.ac.uk
Abstract:
AIDS-associated lung cancer has an increasing incidence, unaccounted for by smoking, and occurs consistently at a younger age than matched controls. We investigated whether known and new cancer-associated polyomaviruses, including the newly identified Merkel cell virus, may play a role in its etiopathogenesis. Although viruses target conserved pathways in cellular evolution, we are unable to suggest that the viruses studied here induce novel mechanisms of oncogenic dysregulation in AIDS-associated lung cancer.
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