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Related Experiment Video

Updated: Jun 13, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

Array-based genomic resequencing of human leukemia.

Y Yamashita1, J Yuan, I Suetake

  • 1Division of Functional Genomics, Jichi Medical University, Tochigi, Japan.

Oncogene
|April 20, 2010
PubMed
Summary
This summary is machine-generated.

Researchers identified novel gene mutations in leukemia, including a Janus kinase 3 (JAK3) mutation with transforming potential and a DNA methyltransferase 3A (DNMT3A) mutation that reduced DNA methylation activity. These findings offer new insights into leukemia oncogenesis.

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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Related Experiment Videos

Last Updated: Jun 13, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Leukemia pathogenesis involves complex genetic alterations.
  • Identifying novel oncogenes is crucial for targeted therapies.

Purpose of the Study:

  • To identify oncogenes in acute myeloid leukemia (AML) and myeloproliferative disorders (MPDs).
  • To characterize the functional impact of newly identified mutations.

Main Methods:

  • Large-scale resequencing of 5648 protein-coding genes in leukemia genomes.
  • Hybridization of genomic DNA using DNA sequence arrays.
  • In vitro and in vivo functional assays for identified mutations.

Main Results:

  • Identified 11 somatic mutations exclusive to leukemia blasts.
  • Discovered a JAK3(M511I) mutation exhibiting transforming potential.
  • Found a DNMT3A mutation causing >50% loss of DNA methylation activity.
  • Detected JAK3 mutations in 9 out of 286 leukemia cases.

Conclusions:

  • The study reveals a unique profile of gene mutations in human leukemia.
  • JAK3 and DNMT3A mutations represent potential oncogenic drivers.
  • These findings contribute to understanding leukemia genomics and therapeutic strategies.