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Updated: Jun 13, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
Rituximab-induced polymorphic ventricular tachycardia
Joseph T Poterucha1, Mark Westberg, Pamela Nerheim
1Department of Internal Medicine & Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA. jpoteruc@unmc.edu
Abstract:
The anti-CD20 monoclonal antibody rituximab is an effective treatment for small lymphocytic lymphoma; however, it has been associated with infusion reactions, including cardiac arrhythmias. Severe cardiac arrhythmia is an adverse reaction that is related to rituximab chemotherapy, and more investigation is warranted into the adverse reactions of rituximab that involve cardiac conduction abnormalities. Herein, we report what we believe to be the 1st case of symptomatic polymorphic ventricular tachycardia to have occurred during an initial infusion of rituximab.
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