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Related Experiment Video

Updated: Jun 13, 2026

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
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Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights

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Mandibular function is severely impaired in systemic sclerosis patients.

Edna Livia A Ferreira, Romy B Christmann, Eduardo F Borba

    Journal of Orofacial Pain
    |April 20, 2010
    PubMed
    Summary

    Systemic sclerosis (SSc) patients frequently experience temporomandibular disorders (TMD), impacting jaw mobility. Severe TMD signs were notably common in SSc, with associations to skin fibrosis severity and treatment.

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    Area of Science:

    • Rheumatology
    • Oral Medicine
    • Dermatology

    Background:

    • Systemic sclerosis (SSc) is a complex autoimmune disease characterized by fibrosis affecting skin and internal organs.
    • Temporomandibular disorders (TMD) involve pain and dysfunction in the jaw joint and muscles.
    • The prevalence and impact of TMD in SSc patients, particularly concerning skin involvement, require further investigation.

    Purpose of the Study:

    • To investigate the occurrence of temporomandibular disorders (TMD) in patients with systemic sclerosis (SSc).
    • To explore the potential association between TMD severity and the extent of skin involvement in SSc patients.
    • To analyze jaw mobility and its correlation with disease characteristics in SSc.

    Main Methods:

    • The study included 35 women with SSc and 30 healthy controls.

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    Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
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  • Temporomandibular disorders (TMD) were assessed using the anamnestic (A(i)) and clinical (D(i)) Helkimo indices.
  • Jaw mobility (M(I)) and skin involvement (Modified Rodnan Skin Score - MRSS) were quantified.

    • Main Results:

    • TMD signs and symptoms were significantly more prevalent in SSc patients compared to controls (P < .001).
    • Severe TMD (D(i)III) was observed in 20% of SSc patients, versus none in controls.
    • Impaired jaw mobility was significantly higher in SSc patients (P < .001), with 77.1% experiencing severe impairment (M(I)II).
    • Patients with severe TMD or jaw mobility issues were more likely to receive cyclophosphamide treatment for severe cutaneous fibrosis.

    Conclusions:

    • Severe temporomandibular disorders (TMD) are highly prevalent in systemic sclerosis (SSc) patients.
    • The findings suggest a significant link between TMD, jaw mobility, and the severity of skin fibrosis in SSc.
    • Further research is warranted to understand the pathophysiology and management implications of TMD in SSc.