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Updated: Jun 13, 2026

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
Published on: December 15, 2017
Rational design for over-production of desirable microbial metabolites by precision engineering
Hong Gao1, Xianlong Zhou, Zhongxuan Gou
1Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, People's Republic of China.
Abstract:
Microbes represent a valuable source of commercially significant natural products that have improved our quality of life. Precision engineering can be used to precisely identify and specifically modify genes responsible for production of natural products and improve this production or modify the genes creating products that would not otherwise be produced. There have been several success stories concerning the manipulation of regulatory genes, pathways, and genomes to increase the productivity of industrial microbes. This review will focus on the strategies and integrated approaches for precisely deciphering regulatory genes by various modern techniques. The applications of precision engineering in rational strain improvement also shed light on the biology of natural microbial systems.
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