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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Allergic Reactions02:06

Allergic Reactions

Overview

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Related Experiment Video

Updated: Jun 13, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

A complex role for complement in allergic asthma.

Xun Zhang1, Jörg Köhl

  • 1Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, OH 45229, USA.

Expert Review of Clinical Immunology
|April 21, 2010
PubMed
Summary
This summary is machine-generated.

Complement fragments C3a and C5a drive allergic asthma inflammation. C5a protects against maladaptive Th2 immunity during sensitization, while C3a and C5a synergize during the effector phase.

Keywords:
Th2 cytokineallergic asthmaanaphylatoxincomplementdendritic cellinnate immunity

Related Experiment Videos

Last Updated: Jun 13, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Area of Science:

  • Immunology
  • Innate Immunity
  • Allergic Inflammation

Background:

  • Allergic asthma is a chronic upper airway inflammatory disease.
  • Maladaptive T helper 2 (Th2) immunity drives the allergic phenotype, but mechanisms are unclear.
  • Complement system activation, particularly C3 and C5 fragments (C3a, C5a), is implicated in asthma pathogenesis.

Purpose of the Study:

  • To review recent findings on complement's role in allergic asthma.
  • To evaluate the therapeutic potential of complement targeting in allergic asthma.

Main Methods:

  • Review of experimental allergic asthma models.
  • Analysis of complement fragment (C3a, C5a) functions during sensitization and effector phases.

Main Results:

  • C5a plays a dominant role during allergen sensitization, preventing maladaptive Th2 immunity.
  • C3a and C5a act synergistically to promote allergic inflammation during the effector phase.

Conclusions:

  • Complement fragments C3a and C5a have distinct roles in allergic asthma development and progression.
  • Targeting the complement system may offer a therapeutic strategy for allergic asthma.