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Serotonin-induced region-specific responses of the arcuate and ventromedial hypothalamic nuclei
Yousheng Jia1, Mostafa El-Haddad, Alfred Gendy
1Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, California 90502, USA.
Abstract:
The arcuate nucleus (ARC) modulates both satiety and hunger signals at the lateral and medial sites, respectively, though these competing responses may be both mediated by serotonin (5-HT). We sought to determine region-specific effects of 5-HT on ARC neurons. Electrical activities in rat hypothalamic slices were simultaneously recorded with an extracellular multielectrode array. 5-HT effects on the ARC were region-specific: primary inhibition of medial ARC and stimulation of lateral ARC neurons. 5-HT primarily inhibited ventromedial nucleus neurons. These results suggest ARC region-specific responses to 5-HT consistent with the anatomical location of lateral ARC anorexigenic proopiomelanocortin neurons and medial ARC orexigenic neuropeptide Y neurons.
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