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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Immunomodulation of the allergic inflammatory response: new developments.

Maria I Araujo1, Regis A Campos, Luciana S Cardoso

  • 1Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil. mia@ufba.br

Inflammation & Allergy Drug Targets
|April 21, 2010
PubMed
Summary

Helminth infections may protect against allergic diseases by modulating immune responses. This involves cytokines like IL-10 and regulatory cells, offering new therapeutic avenues for allergies.

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Last Updated: Jun 13, 2026

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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Murine Model of Allergen Induced Asthma
08:05

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Published on: May 14, 2012

Area of Science:

  • Immunology
  • Molecular mechanisms of allergic diseases

Background:

  • Allergic diseases involve complex pathogenesis with Th1/Th2 cells and cytokines like IL-25 and IL-33.
  • Regulatory mechanisms, including IL-10 and regulatory cells, are crucial in controlling allergic inflammation.
  • IL-10 decreases IgE production and inhibits mast cell mediator release.

Purpose of the Study:

  • To explore the role of helminth infections in modulating allergic immune responses.
  • To investigate the mechanisms underlying the protective effects of helminth infections against allergies.
  • To identify new therapeutic strategies for allergic diseases based on immune modulation.

Main Methods:

  • In vitro studies on asthmatic individuals from schistosomiasis-endemic areas.
  • Analysis of immune modulation involving IL-10, monocytes, CD4+CD25+ T regulatory cells, and CTLA-4 expression.
  • Research on using parasite antigens to modulate allergic inflammation.

Main Results:

  • Helminth infections are associated with high IL-10 levels.
  • In vitro studies show Th2 response modulation in asthmatics from endemic areas.
  • Mechanisms involve IL-10 production and CTLA-4 expression on T cells.

Conclusions:

  • Helminth infections show potential protective effects against allergic diseases.
  • IL-10 and regulatory T cells play a significant role in immune modulation.
  • Parasite antigen-based therapies offer promising new perspectives for treating allergic diseases.