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Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
Published on: January 20, 2017
Recent Progress on Computer-Aided Inhibitor Design of H5N1 Influenza A Virus
Xiaoli Guo, Jing-Fang Wang, Yisheng Zhu
1Department of Bioinformatics and Biostatistics, College of Life Sciences and Biotechnology, Shanghai Jiaotong University, Room 4-321, Life Science Building, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China. dqwei@sjtu.edu.cn.
Abstract:
Design of novel H5N1 inhibitors is currently a research topic of vital importance owing to both a recent pandemic threat by the worldwide spread of H5N1 avian influenza and the high resistance of H5N1 virus to the most widely used commercial drug, oseltamivir-OTV (Tamiflu). There has been much progress in this field recently. This review covers recent work on bioinformatics studies, structure based design, computer modeling and molecular dynamics simulations.
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