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Published on: September 24, 2020

Upper gastrointestinal problems in inhalational ketamine abusers.

Tai Lun Poon1, Ka Fai Wong, Man Yee Chan

  • 1Department of Surgery, Tuen Mun Hospital, Hong Kong SAR, China.

Journal of Digestive Diseases
|April 21, 2010
PubMed
Summary

Inhalational ketamine abuse is frequently linked to upper gastrointestinal (GI) problems, particularly epigastric pain. Abstinence from ketamine abuse significantly relieves these symptoms, offering a crucial message for affected individuals.

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Published on: October 23, 2018

Area of Science:

  • Gastroenterology
  • Toxicology
  • Addiction Medicine

Background:

  • Upper gastrointestinal (GI) problems are common among individuals abusing inhalational ketamine.
  • Epigastric pain is the most frequent GI symptom reported by ketamine abusers.

Purpose of the Study:

  • To investigate the association between inhalational ketamine abuse and upper GI issues.
  • To determine if abstinence from ketamine leads to relief of GI symptoms.

Main Methods:

  • A retrospective study of 37 ketamine abusers (2001-2008) with upper GI symptoms.
  • Exclusion criteria included prior GI issues, NSAID/aspirin use, and known Helicobacter pylori (H. pylori) infection.
  • Upper GI endoscopy was performed on 14 patients; H. pylori testing was negative.

Main Results:

  • Gastritis was the most common endoscopic finding (85.7%), with H. pylori-negative gastritis in 78.6% of cases.
  • Abstinence from ketamine was significantly associated with symptom relief (P=0.027).
  • Logistic regression indicated a 12.5-fold increased odds of symptomatic relief with ketamine abstinence (95% CI[1.20, 130.6], P=0.035).

Conclusions:

  • Ketamine abusers commonly experience upper GI symptoms, primarily epigastric pain.
  • Abstinence from ketamine abuse is a key factor in achieving symptomatic relief.
  • Continued ketamine use is associated with persistent GI symptoms, even with medication.