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Updated: Jun 13, 2026

Operant Sensation Seeking in the Mouse
Published on: November 10, 2010
Using sensation seeking to target adolescents for substance use interventions
James D Sargent1, Susanne Tanski, Mike Stoolmiller
1Cancer Control Research Program, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA. james.d.sargent@dartmouth.edu
Sensation seeking effectively identifies adolescents at risk for binge drinking and smoking. This research provides guidance for optimizing prevention program targeting based on intervention needs.
Area of Science:
- Adolescent health
- Substance use prevention
- Psychological predictors
Background:
- Adolescent substance use remains a significant public health concern.
- Optimizing prevention programs requires accurate identification of at-risk individuals.
- Sensation seeking is a personality trait potentially linked to adolescent risk-taking behaviors.
Purpose of the Study:
- To evaluate the predictive validity of sensation seeking for adolescent substance use.
- To inform the targeting strategies for substance use prevention initiatives.
- To determine optimal cut-off points for sensation seeking to identify at-risk youth.
Main Methods:
- A longitudinal study involving 6522 US adolescents (aged 10-14 at baseline).
- Data collected via random-digit dial telephone surveys over three follow-up waves.
- Logistic regression and receiver operating characteristics curves (AROC) used to assess predictive validity for binge drinking and smoking onset.
Main Results:
- Sensation seeking moderately predicted binge drinking onset (AROC = 0.71).
- Sensation seeking was a stronger predictor of established smoking onset (AROC = 0.80).
- Predictive validity varied by ethnicity, being lower for binge drinking in Black adolescents and higher for smoking in Hispanic adolescents.
Conclusions:
- Sensation seeking is a moderately effective tool for identifying adolescents at risk for initiating binge drinking and smoking.
- The findings support the use of sensation seeking in targeted prevention efforts.
- This study provides a framework for selecting appropriate targeting thresholds considering intervention efficacy, costs, and risks.
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