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Prostaglandin E2 suppresses beta1-integrin expression via E-prostanoid receptor in human monocytes/macrophages

Shunji Hasegawa1, Takashi Ichiyama, Fumitaka Kohno

  • 1Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Japan. shunji@yamaguchi-u.ac.jp

Cellular Immunology
|April 21, 2010
PubMed
Summary

Prostaglandin E2 (PGE2) significantly reduces beta1-integrin expression in human monocytes and macrophages. This anti-inflammatory effect is primarily mediated by the EP4 receptor, highlighting its role in immune cell regulation.

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