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Updated: Jun 13, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
Published on: May 22, 2018
Protein annotation in the era of personal genomics
Thomas Blicher1, Ramneek Gupta, Agata Wesolowska
1NNF Center for Protein Research, Faculty of Health Sciences, Blegdamsvej 3b, DK-2200 Copenhagen N, Denmark. Thomas.Blicher@cpr.ku.dk
Abstract:
Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular - the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health.
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