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Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Spermatogenesis01:22

Spermatogenesis

Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Oogenesis01:22

Oogenesis

Oogenesis,  the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is known...
Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...

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Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
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Oestrogens and spermatogenesis.

Serge Carreau1, Rex A Hess

  • 1Department of Biochemistry, University of Caen, EA 2608, USC 2006 INRA, IFR 146, 14032 Caen, France.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|April 21, 2010
PubMed
Summary
This summary is machine-generated.

Oestrogens play a role in male reproductive physiology. The balance of androgens and oestrogens, modulated by aromatase, influences male gonad function and spermatogenesis.

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Area of Science:

  • Reproductive Endocrinology
  • Male Reproductive Physiology
  • Endocrinology

Background:

  • The role of oestrogens in the male reproductive tract has been debated.
  • The testis produces oestrogenic hormones via aromatase.
  • Oestrogen receptors alpha (ESR1) and beta (ESR2) are expressed in the testis and epididymis.

Purpose of the Study:

  • To review the presence and activity of aromatase and oestrogen receptors in the testis and sperm.
  • To explore the potential roles of oestrogens in mammalian spermatogenesis.

Main Methods:

  • Literature review of current knowledge on aromatase and oestrogen receptors in the male reproductive system.

Main Results:

  • Aromatase and oestrogen receptors are present in the testis and sperm.
  • Oestrogens are involved in the physiology of the male gonad.
  • A balance of androgens and oestrogens, modulated by aromatase, is crucial for male reproductive function.

Conclusions:

  • Oestrogens are integral to male reproductive tract physiology.
  • Aromatase acts as a modulator in the delicate balance of androgens and oestrogens.
  • This hormonal interplay influences mammalian spermatogenesis.