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Spermatogenesis

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...

Spermatogenesis

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Related Experiment Video

Updated: Jun 13, 2026

Serial Enrichment of Spermatogonial Stem and Progenitor Cells (SSCs) in Culture for Derivation of Long-term Adult Mouse SSC Lines

Serial Enrichment of Spermatogonial Stem and Progenitor Cells (SSCs) in Culture for Derivation of Long-term Adult Mouse SSC Lines

Published on: February 25, 2013

Spermatogonial stem cell regulation and spermatogenesis.

Bart T Phillips¹, Kathrin Gassei, Kyle E Orwig

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, 204 Craft Avenue, Pittsburgh, PA, USA.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

|April 21, 2010

Summary

This review covers spermatogonial stem cells (SSCs) and their crucial role in sperm production. Understanding SSC biology advances stem cell research and potential therapeutic applications.

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Serial Enrichment of Spermatogonial Stem and Progenitor Cells (SSCs) in Culture for Derivation of Long-term Adult Mouse SSC Lines

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Area of Science:

Reproductive Biology
Stem Cell Science

Background:

Spermatogonial stem cells (SSCs) are essential for maintaining the continuous process of spermatogenesis.
The study of SSCs is critical for understanding male fertility and developing reproductive therapies.

Purpose of the Study:

To provide an updated review of spermatogonial stem cells (SSCs).
To elucidate the role of SSCs in maintaining the spermatogenic lineage.
To discuss the experimental tools and research advancements in SSC biology.

Main Methods:

Review of existing literature on spermatogonial stem cells.
Description of experimental tools utilized in SSC research.
Analysis of studies enhancing the understanding of stem cell biology and spermatogenesis.

Main Results:

Updated insights into SSC biology and their function in spermatogenesis.
Comprehensive overview of methodologies employed in SSC research.
Demonstration of how SSC knowledge aids in practical applications.

Conclusions:

Advancements in understanding SSCs offer significant potential for manipulation and application.
Future research directions for both fundamental and applied aspects of SSCs are outlined.