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Related Experiment Video

Updated: Jun 13, 2026

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice
09:33

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice

Published on: March 22, 2018

Auditory discrimination learning and knowledge transfer in mice depends on task difficulty.

Simone Kurt1, Günter Ehret

  • 1Institute of Neurobiology, University of Ulm, D-89081 Ulm, Germany. simone.kurt@uni-ulm.de

Proceedings of the National Academy of Sciences of the United States of America
|April 21, 2010
PubMed
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Mice show how learning transfers between auditory tasks. They learn better when moving from complex to simple tasks, but struggle transferring knowledge from simple to complex ones.

Area of Science:

  • Auditory perception and learning
  • Animal models in cognitive research

Background:

  • Human studies reveal complex patterns in auditory discrimination learning and knowledge transfer.
  • Mice exhibit similar phenomena, including advantages in hard-to-easy transfer and disadvantages in easy-to-hard transfer.
  • These effects are linked to procedural knowledge, information-integration learning, and generalization across stimulus classes.

Purpose of the Study:

  • To investigate auditory discrimination learning and knowledge transfer in mice.
  • To determine if mice exhibit hard-to-easy and easy-to-hard transfer effects similar to humans.
  • To establish mice as a model for studying the genetics of auditory perception and learning.

Main Methods:

  • House mice (NMRI strain) were trained on a shuttle-box stimulus discrimination task.

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Related Experiment Videos

Last Updated: Jun 13, 2026

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice
09:33

An Objective and Reproducible Test of Olfactory Learning and Discrimination in Mice

Published on: March 22, 2018

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning
10:36

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

An Operant Intra-/Extra-dimensional Set-shift Task for Mice
08:35

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

Published on: January 22, 2016

  • Two types of discrimination were used: pure tone (PT) and amplitude-modulated (AM) tone.
  • Knowledge transfer between PT and AM tasks was assessed in both directions (PT-to-AM and AM-to-PT).

    • Main Results:

    • Mice learned PT discrimination (easy task) rapidly, while AM discrimination (hard task) was slower and less accurate.
    • No knowledge transfer occurred when mice were trained on PT followed by AM (easy-to-hard).
    • Mice benefited from knowledge transfer when trained on AM followed by PT (hard-to-easy).
    • Confusion of conditioned stimuli occurred when AM carrier frequency matched PT frequencies.

    Conclusions:

    • Mice demonstrate a hard-to-easy knowledge transfer effect in auditory discrimination tasks.
    • Mice exhibit an inability to generalize across perceptually different auditory stimuli in easy-to-hard transfer.
    • Mice serve as a valuable animal model for auditory perception and learning research, including genetic studies.