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Updated: Jun 13, 2026

Robot-Assisted Kidney Transplantation
Published on: July 19, 2021
Seroprevalence of herpes simplex virus-2 in kidney transplant recipients: a single-center experience
Zakieh Rostamzadeh Khameneh1, Nariman Sepehrvand, Ali Taghizadeh-Afshari
1Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran. nariman256@gmail.com
Introduction:
Viral infections are a real threat in kidney transplant recipients because of their immunocompromised condition. This study aimed to evaluate herpes simplex virus-2 (HSV-2) seropositivity among kidney transplant recipients.
Materials And Methods:
Serum samples of 91 kidney transplant recipients from Urmia, Iran, were examined serologically for antibodies against HSV-2 using an enzyme-linked immunosorbent assay.
Results:
The mean time from transplantation at HSV-2 testing was 5.04 +/- 4.45 years. The anti-HSV-2 immunoglobulin G antibody was positive in 5.4% of the kidney transplant recipients. Seropositive patients did not present any clinical manifestations of genital herpes infection. There was no association between HSV-2 seropositivity and age, gender, history of hemodialysis and transplantation, blood transfusion, or immunosuppressive regimen.
Conclusions:
Seroprevalence of HSV-2 is not high among our kidney transplant recipients. However, it remains a source of concern, considering the compromised immune system in this specific population.
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