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Published on: April 4, 2018
NRAMP1 (SLC11A1) variants: genetic susceptibility to multiple Sclerosis
Omer Ates1, Semiha Kurt, Nihan Bozkurt
1Department of Medical Biology, Medical Faculty, Gaziosmanpasa University, 60100, Tokat, Turkey. omerates27@yahoo.com
Objectives:
Multiple sclerosis (MS) is an inflammatory, autoimmune demyelinating disease of the central nervous system. Human Natural Resistance Associated Macrophage Protein 1 (NRAMP1) gene polymorphisms have been implicated in the immune mediated diseases susceptibility. This study aimed to investigate the plausible association between NRAMP1 gene and MS susceptibility.
Methods:
We analyzed (GT)(n,) INT4, 3'UTR and D543N polymorphisms of NRAMP1 gene in 100 MS patients and 104 healthy subjects by using amplification refractory mutation system-polymerase chain reaction and sequence analysis.
Results:
No significant association was found between (GT)(n,) INT4, 3'UTR and D543N polymorphisms and MS. There was also no correlation between NRAMP1 polymorphisms and MS clinical forms.
Conclusions:
Our findings suggest that NRAMP1 polymorphisms do not play a role in MS susceptibility and clinical finding of MS in Turkish patients.
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