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Overexpression of alpha-synuclein down-regulates BDNF expression.

Yuhe Yuan1, Jiandong Sun, Ming Zhao

  • 1Key Laboratory of Bioactive Substances and Resources Utilization, Ministry of Education, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.

Cellular and Molecular Neurobiology
|April 21, 2010
PubMed
Summary

Alpha-synuclein overexpression in Parkinson's disease (PD) reduces brain-derived neurotrophic factor (BDNF) by disrupting signaling pathways. This study elucidates a key mechanism in PD pathogenesis involving alpha-synuclein and BDNF.

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