Related Experiment Video
Updated: Jun 13, 2026
09:53
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Cavernous sinus meningiomas: a large LINAC radiosurgery series
Roberto Spiegelmann1, Zvi R Cohen, Ouzi Nissim
1Department of Neurosurgery, The Chaim Sheba Medical Center, 52621, Tel Hashomer, Israel. Spiegel@sheba.health.gov.il
Journal of Neuro-Oncology
|April 21, 2010
Summary
LINAC radiosurgery effectively controls cavernous sinus meningiomas, with 98% tumor control and significant improvement in cranial nerve deficits. Early treatment of neuropathy yields better outcomes with minimal complications.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Neurology
Background:
- Cavernous sinus meningiomas are complex skull base tumors.
- LINAC radiosurgery is an established treatment modality.
Purpose of the Study:
- To evaluate the efficacy and safety of LINAC radiosurgery for cavernous sinus meningiomas.
- To assess tumor control rates and impact on cranial nerve deficits.
Main Methods:
- 102 patients with cavernous sinus meningiomas underwent LINAC radiosurgery between 1993-2007.
- High-resolution MRI and stereotactic CT were used for treatment planning.
- Tumor margins received 12-17.5 Gy, with optic apparatus dose <10 Gy.
Main Results:
- 98% tumor control rate observed over a mean follow-up of 67 months.
- 58% of tumors showed volume reduction.
- 39% of patients with cranial nerve deficits experienced improvement or resolution, particularly with early treatment.
Conclusions:
- LINAC radiosurgery is a safe and effective treatment for cavernous sinus meningiomas.
- It achieves high tumor control rates with few, mild complications.
- Early radiosurgery can significantly improve outcomes for cranial neuropathies.
