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Updated: Jun 13, 2026
07:35
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
[Renal dynamics: comparison between diuretic renogram and magnetic resonance imaging]
F Cáceres1, J Rodó Salas, A Capdevila
1Urología Pediátrica, Cirugía Pediátrica, Agrupación Sanitaria Hospital Sant Joan de Déu-Clínic, Universidad de Barcelona. fcaceres@hsjdbcn.org
Summary
Magnetic resonance with gadolinium and furosemide (MR-Gd/F) shows high consistency with diuretic renogram (DR) for renal function assessment. MR-Gd/F offers greater diagnostic precision, particularly for non-obstructive findings.
Area of Science:
- Urology
- Radiology
- Pediatric Nephrology
Background:
- Diuretic renogram (DR) is a standard for assessing differential renal function (DRF) and renographic curves (RC).
- Magnetic resonance imaging (MRI) offers anatomical and vascular insights, but its functional assessment with diuretics is less established.
Purpose of the Study:
- To compare renal functional data from MR-Gd/F with parameters from conventional DR.
- To evaluate the diagnostic accuracy of MR-Gd/F versus DR in pediatric renal pathologies.
Main Methods:
- 10 pediatric patients (1 month-6 years) with various renal anomalies underwent both MR-Gd/F and DR.
- Furosemide was used as a diuretic challenge in both imaging modalities.
- Gadolinium uptake percentages and MR curves were compared with DRF and RC, respectively.
Main Results:
- MR-Gd/F demonstrated 80% consistency with DRF and 90% correlation with RC.
- MR-Gd/F improved diagnostic accuracy to 90% in operated cases, compared to 60% for DR (p > 0.0008).
- MR-Gd/F influenced surgical decisions in two cases, leading to conservative management.
Conclusions:
- MR-Gd/F provides accurate real-time anatomical, vascular, and functional renal assessment.
- The technique shows good correlation with DR parameters (%DRF, %Gd MR, diuretic curve).
- MR-Gd/F offers superior diagnostic precision and aids in identifying non-obstructive findings for conservative management.
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