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Automated Lipid Bilayer Membrane Formation Using a Polydimethylsiloxane Thin Film
Published on: July 10, 2016
Sealing of submicrometer wells by a shear-driven lipid bilayer
Peter Jönsson1, Magnus P Jonsson, Fredrik Höök
1Department of Applied Physics, Chalmers University of Technology, Gothenburg, Sweden. jopeter@chalmers.se
Nano Letters
|April 22, 2010
Abstract:
A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.
