Novel polyesterified 3,4-seco-grayanane diterpenoids as antifeedants from Pieris formosa

Pieris formosa is a poisonous plant to livestock and is used as an insecticide in rural areas of China. Two novel polyesterified 3,4-seco-grayanane diterpenoids, pierisoids A and B (1 and 2), were isolated from its flowers and were identified by spectroscopic analysis and X-ray diffraction. Both compounds showed obvious antifeedant activity against cotton bollworm, indicating their toxic properties, suggesting a defensive role of polyesterified 3,4-seco-grayanane diterpenoids for P. formosa against herbivores.