Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Influencing Bioavailability: First-Pass Elimination01:23

Factors Influencing Bioavailability: First-Pass Elimination

8.7K
When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
8.7K
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

780
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
780
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

2.0K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
2.0K
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

692
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
692
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

455
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
455
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

313
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
313

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Rationally engineered essential oil-loaded nanocarriers for acne vulgaris: integrating multiscale molecular modeling, machine learning, and response surface optimization.

Journal of microencapsulation·2026
Same journal

Retinyl palmitate-loaded nanostructured lipid carriers prepared by the phase inversion temperature method: Physicochemical properties, <i>in vitro</i> skin permeation, and occlusion ability.

Journal of microencapsulation·2026
Same journal

Green synthesis of silver nanoparticles using <i>Swertia chirayita</i> and their antioxidant and anticancer potential.

Journal of microencapsulation·2026
Same journal

Management of coronary artery disease via simvastatin-loaded novasomes.

Journal of microencapsulation·2026
Same journal

Phyto-engineered CuO nanoparticles from gum <i>Eucalyptus camaldulensis</i>: a GC-MS, molecular docking, and bioactivity study.

Journal of microencapsulation·2026
Same journal

Development and optimization of gallic acid-enriched nanostructured lipid carriers for the amelioration of rheumatic inflammation: <i>in-vitro</i> and <i>in-vivo</i> study.

Journal of microencapsulation·2026

Related Experiment Video

Updated: Apr 13, 2026

High Throughput Single-cell and Multiple-cell Micro-encapsulation
16:19

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

19.3K

Microencapsulation techniques, factors influencing encapsulation efficiency.

N Venkata Naga Jyothi1, P Muthu Prasanna, Suhas Narayan Sakarkar

  • 1Department of Pharmaceutics, Hindu College of pharmacy, Guntur, Andhra Pradesh, India. nvn.jyothi567@gmail.com

Journal of Microencapsulation
|April 22, 2010
PubMed
Summary
This summary is machine-generated.

Microencapsulation protects sensitive substances and creates novel materials by enclosing particles in a polymer shell. This review explores various microencapsulation techniques and factors affecting their efficiency.

More Related Videos

Extraction of Plant-based Capsules for Microencapsulation Applications
10:54

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

12.7K
Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

8.5K

Related Experiment Videos

Last Updated: Apr 13, 2026

High Throughput Single-cell and Multiple-cell Micro-encapsulation
16:19

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

19.3K
Extraction of Plant-based Capsules for Microencapsulation Applications
10:54

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

12.7K
Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

8.5K

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Pharmaceutical Sciences

Background:

  • Microencapsulation is a key technique for preserving sensitive substances.
  • It involves creating materials with enhanced properties by encapsulating particles within a polymeric shell.
  • Various microencapsulation methods exist for drug delivery applications.

Purpose of the Study:

  • To review diverse microencapsulation techniques.
  • To identify critical factors influencing encapsulation efficiency.
  • To provide a comprehensive literature overview for researchers and practitioners.

Main Methods:

  • Literature review of scientific articles and publications.
  • Analysis of different microencapsulation processes.
  • Identification and categorization of factors affecting encapsulation efficiency.

Main Results:

  • Detailed description of various microencapsulation techniques.
  • Elucidation of key parameters impacting encapsulation efficiency, including polymer concentration, solubility, and solvent properties.
  • Synthesis of current knowledge on microencapsulation.

Conclusions:

  • Microencapsulation offers significant advantages for quality preservation and material innovation.
  • Understanding the factors influencing encapsulation efficiency is crucial for optimizing microparticle production.
  • This review serves as a valuable resource for selecting and implementing appropriate microencapsulation strategies.