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Old age and outcome after primary angioplasty for acute myocardial infarction

Menko-Jan de Boer1, Jan Paul Ottervanger, Harry Suryapranata

  • 1Department of Cardiology, Isala Klinieken, Locatie Weezenlanden, Zwolle, the Netherlands. ereis@planet.nl

Journal of the American Geriatrics Society
|April 22, 2010
PubMed

Insights

Older age independently increases mortality risk after acute myocardial infarction (AMI) treated with percutaneous coronary intervention (PCI). Patients 75 and older face the highest mortality risk, highlighting age as a critical prognostic factor.

Area of Science:

  • Cardiology
  • Geriatric Medicine
  • Interventional Cardiology

Background:

  • Acute myocardial infarction (AMI) is a leading cause of mortality worldwide.
  • Percutaneous coronary intervention (PCI) is a primary treatment for AMI.
  • The impact of age on AMI prognosis after PCI requires further elucidation.

Purpose of the Study:

  • To evaluate age as an independent predictor of prognosis in patients with AMI undergoing primary PCI.
  • To compare clinical outcomes across different age strata after PCI for AMI.

Main Methods:

  • Retrospective analysis of a dedicated database from a high-volume interventional cardiology center.
  • Inclusion of 4,933 consecutive patients with AMI treated with PCI.
  • Comparison of baseline characteristics and 30-day/1-year outcomes across age groups (e.g., <65, 65-74, ≥75 years).

Main Results:

  • Older age was independently associated with increased mortality after PCI for AMI.
  • Patients aged 65-74 had a higher risk of 1-year mortality compared to those <65 (AOR=1.57).
  • Patients aged ≥75 had a significantly higher risk of 1-year mortality compared to those <65 (AOR=3.03).

Conclusions:

  • Advanced age is an independent risk factor for mortality following PCI for AMI.
  • Patients aged 65 and older, particularly those 75 and older, experience substantially higher mortality risks.
  • Age stratification is crucial for risk assessment and management in AMI patients treated with PCI.
Abstract

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