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Related Concept Videos

Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 13, 2026

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

Mouse Models for Type 1 Diabetes.

T L Van Belle1, P Taylor, M G von Herrath

  • 1Diabetes Center, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA.

Drug Discovery Today. Disease Models
|April 22, 2010
PubMed
Summary

Animal models, like the non-obese diabetic (NOD) mouse, have been crucial for understanding Type 1 Diabetes (T1D) genetics and pathogenesis. This review overviews current mouse models for T1D research.

Area of Science:

  • Immunology
  • Genetics
  • Endocrinology

Background:

  • The discovery of animal models, particularly the non-obese diabetic (NOD) mouse, significantly advanced the understanding of Type 1 Diabetes (T1D) genetics, aetiology, and pathogenesis starting in the late 1970s.
  • Subsequent advancements in transgenic and gene-targeting technologies have enabled the creation of numerous mouse models with simplified genetic and pathogenic complexity.

Purpose of the Study:

  • To provide a comprehensive overview of the currently available mouse models for Type 1 Diabetes (T1D) research.
  • To highlight the utility of these models in dissecting specific aspects of T1D pathogenesis.

Main Methods:

  • Literature review of established and emerging mouse models for Type 1 Diabetes.
  • Analysis of genetic modifications and pathogenic characteristics of various T1D mouse models.

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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

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Last Updated: Jun 13, 2026

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Main Results:

  • Identification of a diverse range of mouse models, including the foundational NOD mouse, that recapitulate key features of human T1D.
  • Demonstration of how genetically engineered models allow focused investigation into specific T1D pathways.

Conclusions:

  • Mouse models are indispensable tools for unraveling the complex genetic and pathogenic mechanisms underlying Type 1 Diabetes.
  • The continued development and application of sophisticated mouse models are essential for advancing T1D research and therapeutic strategies.