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Zolmitriptan and human aggression: interaction with alcohol.

Joshua L Gowin1, Alan C Swann, F Gerard Moeller

  • 1Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center Houston, Houston, TX, USA.

Psychopharmacology
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Summary
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Zolmitriptan, a serotonin agonist, effectively reduced alcohol-induced aggression in social drinkers. This study highlights the interaction between the serotonin system and alcohol in modulating human aggressive behavior.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychology

Background:

  • The serotonin 1(B/D) (5-HT1(B/D)) receptor is a potential target for reducing aggression.
  • Zolmitriptan is a 5-HT1(B/D) agonist with potential anti-aggression effects.
  • Alcohol is known to enhance aggression, and its interaction with the serotonin system is of interest.

Purpose of the Study:

  • To investigate zolmitriptan's effect on human aggression across various alcohol doses.
  • To understand alcohol's role in aggression by manipulating the serotonin (5-HT) system.

Main Methods:

  • Eleven social drinkers participated in a 3-4 week study.
  • Aggression was measured using the point-subtraction aggression paradigm (PSAP).
  • Participants received 5-mg zolmitriptan or placebo with alcohol doses (0.0, 0.4, 0.8 g/kg) in a counterbalanced design.

Main Results:

  • A significant interaction between alcohol and zolmitriptan was observed on the aggressive/monetary response ratio.
  • Zolmitriptan decreased the aggressive/monetary ratio at 0.4- and 0.8-g/kg alcohol doses compared to placebo.

Conclusions:

  • A 5-mg dose of zolmitriptan effectively reduced alcohol-related aggression.
  • This study demonstrates an interaction between serotonin and alcohol in human aggressive behavior.