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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jun 13, 2026

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics
04:33

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics

Published on: December 8, 2023

Surface plasmon resonance biosensorics in urine proteomics.

Peter B Luppa1, Jochen Metzger, Heike Schneider

  • 1Institut für Klinische Chemie, Krankenhaus München Rechts der Isar, München, Germany.

Methods in Molecular Biology (Clifton, N.J.)
|April 22, 2010
PubMed
Summary

Surface plasmon resonance (SPR) biosensors offer advanced molecular interaction analysis. This review details SPR

Area of Science:

  • Biophysics and Analytical Chemistry

Background:

  • Surface plasmon resonance (SPR) is a powerful biophysical detection method.
  • SPR biosensors are established tools for studying molecular interactions and interaction proteomics.
  • SPR's analytical capabilities are expanding into quantitative clinical diagnostics.

Purpose of the Study:

  • To review the principles of SPR and its application in biosensing.
  • To explore the use of SPR in urine proteomics and diagnostics.
  • To highlight the potential of SPR biosensors in clinical laboratories and point-of-care testing.

Main Methods:

  • Detailed explanation of the optical phenomena of SPR near gold surfaces.
  • Overview of bioconjugation chemistry for SPR sensing surfaces.
  • Introduction to kinetic analysis for molecular interaction studies using SPR.

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Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
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Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics

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Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

Related Experiment Videos

Last Updated: Jun 13, 2026

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics
04:33

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics

Published on: December 8, 2023

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
10:50

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics

Published on: July 16, 2018

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins
10:05

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

Main Results:

  • SPR facilitates the identification and functional analysis of novel urinary proteins.
  • SPR enables quantitative analysis of proteins and metabolites in complex biological samples like urine.
  • Demonstration of SPR's utility in proteinuria diagnostics.

Conclusions:

  • SPR biosensors are versatile tools for molecular interaction studies and proteomics.
  • SPR shows significant promise for quantitative clinical analysis, including urine diagnostics.
  • The integration of SPR into core labs and point-of-care settings is anticipated.