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Updated: Jun 13, 2026

Hand-Rearing Method for Infant Marmosets
Published on: June 9, 2023
Metabolic fate of phenothiazine in the marmoset (Callithrix jacchus)
Stephen Mitchell1, Glyn Steventon, Rosemary Waring
1Department of Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, South Kensington, UK. s.c.mitchell@imperial.ac.uk
Abstract:
The fate of [35S]-phenothiazine, a veterinary anthelmintic, has been investigated in the adult male marmoset (Callithrix jacchus) following oral administration. A near complete recovery of radioactivity (c. 95%) was achieved in 0-3 days, with just over one-third of the dose (c. 37%) being present in the urine and the remainder (c. 58%) being accounted for in the faeces. The majority of the urinary radioactivity (c. 91%) was present as conjugates, tentatively identified as phenothiazine N-glucuronide and leucophenothiazone sulphate. Smaller amounts of phenothiazone, thionol, phenothiazine sulphoxide and unchanged phenothiazine were also identified. The only compound identified in the faeces was unchanged phenothiazine.
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