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Static Strength Training Method for Type 2 Diabetic Mice
Published on: March 29, 2024
Inspiratory muscle strength is correlated with carnitine levels in type 2 diabetes
Fatih Kiliçli1, Sebila Dökmetaş, Ferhan Candan
1Department of Endocrinology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
Introduction:
Plasma carnitine insufficiency has been known to cause muscle weakness. Carnitine levels and pulmonary functions were lower in patients with diabetes.
Patients And Methods:
To determine whether pulmonary functions are correlated with carnitine levels in patients with type 2 diabetes. In this study, we evaluated pulmonary functions and carnitine concentrations in 49 patients with type 2 diabetes and 34 healthy controls.
Results:
Carnitine levels were lower in type 2 diabetes group than control group (52.56 +/- 12.38 and 78.96 +/- 10.66 hmol/mL, respectively, p < 0.0001). Pulmonary functions were not significantly different between groups. Carnitine levels were not correlated with age, duration of diabetes, fasting blood glucose levels, and glycemic control (HbA1c%) in patients with type 2 diabetes. However, carnitine levels in patient group were correlated with % forced vital capacity (FVC%) (r = 0.35, p = 0.016), % forced expiratory volume in 1 s (FEV1%) (r = 0.318, p= 0.029), FEV1/FVC (r= 0.302, p= 0.039), inspiratory muscle strength (PImax) (r = 0.407, p = 0.023), and PImax% (r = 0.423, p= 0.018).
Conclusion:
This study suggests that low carnitine levels may be associated with lower PImax and PImax% in type 2 diabetes.
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