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Updated: Jun 13, 2026

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
Published on: May 27, 2022
αII-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients
Stefania Mondello1, Steven A Robicsek, Andrea Gabrielli
1Department of Clinical Programs and Center of Innovative Research, University of Florida, Gainesville, Florida, USA.
Abstract:
In this study we assessed the clinical utility of quantitative assessments of alphaII-spectrin breakdown products (SBDP145 produced by calpain, and SBDP120 produced by caspase-3) in cerebrospinal fluid (CSF) as markers of brain damage and outcome after severe traumatic brain injury (TBI). We analyzed 40 adult patients with severe TBI (Glasgow Coma Scale [GCS] score
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