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Related Concept Videos

Colloidal precipitates01:09

Colloidal precipitates

The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...

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Related Experiment Video

Updated: Jun 13, 2026

Evaluating Plasmonic Transport in Current-carrying Silver Nanowires
09:00

Evaluating Plasmonic Transport in Current-carrying Silver Nanowires

Published on: December 11, 2013

Does nanocrystalline silver have a transferable effect?

Patricia L Nadworny1, Breanne K Landry, JianFei Wang

  • 1Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB, Canada.

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [And] the European Tissue Repair Society
|April 23, 2010
PubMed
Summary

Nanocrystalline silver exhibits anti-inflammatory effects by interacting with skin cells, triggering signals that reduce inflammation systemically. This study shows minimal silver penetration but significant remote anti-inflammatory activity.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Dermatology

Background:

  • Nanocrystalline silver (NCS) is recognized for its antimicrobial properties.
  • The anti-inflammatory mechanisms and systemic effects of NCS require further elucidation.

Purpose of the Study:

  • To investigate the mechanism underlying the anti-inflammatory activity of nanocrystalline silver.
  • To evaluate the systemic anti-inflammatory effects of nanocrystalline silver.

Main Methods:

  • Secondary ion mass spectroscopy (SIMS) was used to analyze silver deposition in skin.
  • A porcine contact dermatitis model was employed to assess remote anti-inflammatory effects.
  • Apoptosis, cytokine levels (pro- and anti-inflammatory), and growth factors were analyzed via immunohistochemistry.

Main Results:

  • Silver deposition was primarily superficial, with minimal skin penetration.
  • Remote treatment with NCS on healthy skin improved dermatitis in induced wounds.
  • NCS treatment increased apoptosis in dermal inflammatory cells and modulated cytokine profiles.

Conclusions:

  • The anti-inflammatory effects of NCS are mediated by interactions with superficial skin cells.
  • These interactions lead to the release of biological signals that induce widespread anti-inflammatory activity.
  • NCS demonstrates potential for treating inflammatory skin conditions through a novel signaling mechanism.