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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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Updated: Jun 13, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

Vitamin d deficiency and tuberculosis progression.

Najeeha Talat1, Sharon Perry, Julie Parsonnet

  • 1Aga Khan University, Karachi, Pakistan.

Emerging Infectious Diseases
|April 23, 2010
PubMed
Summary

Vitamin D deficiency is common in tuberculosis patients and contacts. Low vitamin D levels significantly increase the risk of developing tuberculosis disease.

Area of Science:

  • Infectious Diseases
  • Nutritional Science
  • Public Health

Background:

  • Tuberculosis (TB) remains a significant global health challenge.
  • Vitamin D plays a crucial role in immune function and may influence TB susceptibility.
  • Understanding factors associated with TB progression is vital for effective control strategies.

Purpose of the Study:

  • To investigate the association between vitamin D levels and the progression of tuberculosis.
  • To determine the prevalence of vitamin D deficiency in a cohort of TB patients and their contacts in Pakistan.

Main Methods:

  • A cohort study was conducted with 129 tuberculosis patients and their contacts in Pakistan.
  • Vitamin D levels were measured in all participants.
  • Statistical analysis was performed to assess the relationship between vitamin D status and TB progression.

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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
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Main Results:

  • A high prevalence of vitamin D deficiency was observed, with 79% of participants showing insufficient levels.
  • Low vitamin D levels were significantly associated with an increased risk of tuberculosis disease progression.
  • The risk of progression to tuberculosis was approximately 5-fold higher in individuals with low vitamin D levels.

Conclusions:

  • Vitamin D deficiency is highly prevalent in the studied cohort of TB patients and contacts.
  • Maintaining adequate vitamin D levels may be a potential strategy to reduce tuberculosis progression.
  • Further research is warranted to explore vitamin D supplementation as an adjunct therapy for TB prevention and management.